Synthesis, activity and theoretical study of ABT-418 analogues

被引:8
作者
Avenoza, A [1 ]
Busto, JH
Cativiela, C
Dordal, A
Frigola, J
Peregrina, JM
机构
[1] Univ La Rioja, Dept Quim, Grp Sintesis Quim La Rioja, UA,CSIC, Logrono 20006, Spain
[2] Univ Zaragoza, Dept Quim Organ, Inst Ciencia Mat Aragon, CSIC, E-50009 Zaragoza, Spain
[3] Lab Dr Esteve SA, Barcelona 08041, Spain
关键词
amino acids and derivatives; bicyclic heterocyclic compounds; biologically active compounds; isoxazoles; molecular modeling/mechanics;
D O I
10.1016/S0040-4020(02)00388-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This report shows the synthesis and biological evaluation of two new conformationally restricted ABT-418 analogues. This restriction is introduced by the incorporation of the 7-azabicyclo[2.2.1]heptane skeleton. Furthermore, we report here a high-level quantum mechanical study of their conformations in the gas phase. (C) 2002 Published by Elsevier Science Ltd.
引用
收藏
页码:4505 / 4511
页数:7
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