Exploiting the enhanced permeability and retention effect for tumor targeting

被引:1451
作者
Iyer, Arun K.
Khaled, Greish
Fang, Jun
Maeda, Hiroshi [1 ]
机构
[1] Sojo Univ, Fac Pharmaceut Sci, Lab Microbiol & Oncol, Ikeda, Osaka 8620082, Japan
[2] Kumamoto Univ, Cooperat Res Ctr, BioDynam Res Lab, Mashiki, Kumamoto 8600811, Japan
关键词
D O I
10.1016/j.drudis.2006.07.005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is a key mechanism for solid tumor targeting, and considered a gold standard for novel drug design. In this review, we discuss various endogenous factors that can positively impact the EPR effect in tumor tissues. Further, we discuss ways to augment the EPR effect by use of exogenous agents, as well as practical methods available in the clinical setting. Some innovative examples developed by researchers to combat cancer by the EPR mechanism are also discussed.
引用
收藏
页码:812 / 818
页数:7
相关论文
共 81 条
[61]  
Sawa T, 2000, CANCER RES, V60, P666
[62]   TUMOR-CELLS SECRETE A VASCULAR-PERMEABILITY FACTOR THAT PROMOTES ACCUMULATION OF ASCITES-FLUID [J].
SENGER, DR ;
GALLI, SJ ;
DVORAK, AM ;
PERRUZZI, CA ;
HARVEY, VS ;
DVORAK, HF .
SCIENCE, 1983, 219 (4587) :983-985
[63]   INFLUENCE OF MOLECULAR-WEIGHT ON PASSIVE TUMOR ACCUMULATION OF A SOLUBLE MACROMOLECULAR DRUG CARRIER [J].
SEYMOUR, LW ;
MIYAMOTO, Y ;
MAEDA, H ;
BRERETON, M ;
STROHALM, J ;
ULBRICH, K ;
DUNCAN, R .
EUROPEAN JOURNAL OF CANCER, 1995, 31A (05) :766-770
[64]   Exposure to carbon nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells [J].
Shvedova, AA ;
Castranova, V ;
Kisin, ER ;
Schwegler-Berry, D ;
Murray, AR ;
Gandelsman, VZ ;
Maynard, A ;
Baron, P .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2003, 66 (20) :1909-1926
[65]  
SKINNER SA, 1990, CANCER RES, V50, P2411
[66]   PROSTAGLANDIN SYNTHESIS INHIBITION - EFFECT ON BONE CHANGES AND SARCOMA TUMOR INDUCTION IN BALB-C MICE [J].
STRAUSSER, HR ;
HUMES, JL .
INTERNATIONAL JOURNAL OF CANCER, 1975, 15 (05) :724-730
[67]   Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo [J].
Stroh, M ;
Zimmer, JP ;
Duda, DG ;
Levchenko, TS ;
Cohen, KS ;
Brown, EB ;
Scadden, DT ;
Torchilin, VP ;
Bawendi, MG ;
Fukumura, D ;
Jain, RK .
NATURE MEDICINE, 2005, 11 (06) :678-682
[68]  
SUZUKI F, 1993, INT J IMMUNOPHARMACO, V15, P175
[69]   STIMULATION OF NON-SPECIFIC RESISTANCE TO TUMORS IN THE MOUSE USING A POLY(MALEIC-ACID-STYRENE)-CONJUGATED NEOCARZINOSTATIN [J].
SUZUKI, F ;
POLLARD, RB ;
MAEDA, H .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1989, 30 (02) :97-104
[70]  
SUZUKI F, 1990, CANCER RES, V50, P3897