Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data

被引：9

作者：

Liao, DI

Basarab, GS

Gatenby, AA

Jordan, DB

机构：

[1] Dupont Merck Pharmaceut Co, Stine Haskell Res Ctr, Newark, DE 19714 USA

[2] Dupont Co, Cent Res & Dev, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)00037-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Compounds that control rice blast, but not other crop diseases. a ere selected for testing as inhibitors of trihydroxy naphthalene reductase of the fungal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (K-i = 25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex was determined at 2.1 Angstrom resolution. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

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页码：491 / 494

页数：4

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