Novel lipoic acid analogues that inhibit nitric oxide synthase

被引：45

作者：

Harnett, JJ

Auguet, M

Viossat, I

Dolo, C

Bigg, D

Chabrier, PE

机构：

[1] Inst Henri Beaufour, Beaufour Ipsen Res Labs, Dept Med Chem, F-91966 Les Ulis, France

[2] Inst Henri Beaufour, Beaufour Ipsen Res Labs, Dept Biol, F-91966 Les Ulis, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(02)00216-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis and biological activity of novel lipoic acid analogues are reported. Lipoic acid and structural homologues coupled to arylthiophene amidine via carboxamide linkers are metabolic antioxidants capable of protecting neuronal cells against glutamate cytotoxicity, preventing loss of intracellular glutathione, and inhibit nitric oxide synthase. (C) 2002 Published by Elsevier Science Ltd.

引用

收藏

页码：1439 / 1442

页数：4

相关论文

共 25 条

[1]

AUGUET M, Patent No. 0059448

[2]

BERCOT V, 1962, ANN CHIM, V7, P303

[3]

NITRIC-OXIDE - NOVEL BIOLOGY WITH CLINICAL RELEVANCE [J].

BILLIAR, TR .

ANNALS OF SURGERY, 1995, 221 (04) :339-349

[4]

MICROGLIAL-PRODUCED NITRIC-OXIDE AND REACTIVE NITROGEN-OXIDES MEDIATE NEURONAL CELL-DEATH [J].

BOJE, KM ;

ARORA, PK .

BRAIN RESEARCH, 1992, 587 (02) :250-256

[5]

ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

[6]

A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[7]

An efficient synthetic route to 2-(1,2-dithiolan-3-yl)acetic acid. Trisnorlipoic acid and amide derivatives. [J].

Chen, YS ;

Lawton, RG .

TETRAHEDRON LETTERS, 1997, 38 (33) :5785-5788

[8]

PROTEIN-KINASE-C ACTIVATION INHIBITS GLUTAMATE-INDUCED CYTOTOXICITY IN A NEURONAL CELL-LINE [J].

DAVIS, JB ;

MAHER, P .

BRAIN RESEARCH, 1994, 652 (01) :169-173

[9]

HARNETT JJ, Patent No. 0059899

[10]

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms [J].

Ishige, K ;

Schubert, D ;

Sagara, Y .

FREE RADICAL BIOLOGY AND MEDICINE, 2001, 30 (04) :433-446