Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

被引：57

作者：

Lage, H

Helmbach, H

Dietel, M

Schadendorf, D

机构：

[1] Humboldt Univ, Inst Pathol, D-10117 Berlin, Germany

[2] Univ Heidelberg, Clin Cooperat Unit Dermatooncol, DKFZ, D-68135 Mannheim, Germany

[3] Univ Heidelberg, Clin Mannheim, D-68135 Mannheim, Germany

来源：

BRITISH JOURNAL OF CANCER | 2000年 / 82卷 / 02期

关键词：

melanoma; drug resistance; etoposide; cisplatin; fotemustine; vindesine;

D O I：

10.1054/bjoc.1999.0947

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of DNA topoisomerases (Topo) II alpha and II beta was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms. (C) 2000 Cancer Research Campaign.

引用

页码：488 / 491

页数：4

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