Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

被引：332

作者：

Kirby, James ^{[1
]}

Keasling, Jay D. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Calif Inst Quantitat Biomed Res, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA

[5] Joint Bioenergy Inst, Emeryville, CA 94608 USA

来源：

ANNUAL REVIEW OF PLANT BIOLOGY | 2009年 / 60卷

基金：

美国国家科学基金会; 比尔及梅琳达.盖茨基金会;

关键词：

terpenes; P450; yeast; Escherichia coli; gene discovery; ESCHERICHIA-COLI STRAINS; CELL-SUSPENSION CULTURES; HIGH-LEVEL PRODUCTION; 1-DEOXY-D-XYLULOSE-5-PHOSPHATE SYNTHASE; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; CYTOCHROMES P450; SACCHAROMYCES-CEREVISIAE; CINNAMATE; 4-HYDROXYLASE; CAROTENOID ACCUMULATION;

D O I：

10.1146/annurev.arplant.043008.091955

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Isoprenoids are a large and highly diverse group of natural products with many functions in plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl diphosphate precursors through the action of terpene synthases and terpene-modifying enzymes such as cytochrome P450 monooxygenases. Many isoprenoids have important applications in areas such as human health and nutrition, and much effort has been directed toward their production in microbial hosts. However, many hurdles must be overcome in the elucidation and functional microbial expression of the genes responsible for biosynthesis of ail isoprenoid of interest. Here, we review investigations into isoprenoid function and gene discovery in plants as well as the latest advances in isoprenoid pathway engineering in both plant and microbial hosts.

引用

页码：335 / 355

页数：21

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