A Nurr1 Pathway for Neuroprotection

被引：51

作者：

Bensinger, Steven J. ^{[2
,3
]}

Tontonoz, Peter ^{[1
,3
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Inst Mol Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

CELL | 2009年 / 137卷 / 01期

关键词：

PPAR-GAMMA; TRANSREPRESSION;

D O I：

10.1016/j.cell.2009.03.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.

引用

页码：26 / 28

页数：4

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