Frontoparietal Cortex Controls Spatial Attention through Modulation of Anticipatory Alpha Rhythms

被引：359

作者：

Capotosto, Paolo ^{[2
,3
]}

Babiloni, Claudio ^{[1
,4
]}

Romani, Gian Luca ^{[2
,3
]}

Corbetta, Maurizio ^{[2
,3
,5
,6
,7
]}

机构：

[1] Univ Foggia, Dept Biomed Sci, I-71100 Foggia, Italy

[2] Univ G dAnnunzio, Ist Tecnol Avanzate Biomed, I-66013 Chieti, Italy

[3] Univ G dAnnunzio, Dipartimento Sci Clin & Bioimmagini, I-66013 Chieti, Italy

[4] Casa Cura San Raffaele Cassino, I-03043 Cassino, Italy

[5] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63130 USA

[6] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63130 USA

[7] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63130 USA

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 18期

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; HUMAN VISUAL-CORTEX; FRONTAL EYE FIELD; CONCURRENT TMS-FMRI; TOP-DOWN CONTROL; VISUOSPATIAL ATTENTION; OSCILLATORY ACTIVITY; NEURAL MECHANISMS; OCCIPITAL CORTEX; PARIETAL CORTEX;

D O I：

10.1523/JNEUROSCI.0539-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A dorsal frontoparietal network, including regions in intraparietal sulcus (IPS) and frontal eye field (FEF), has been hypothesized to control the allocation of spatial attention to environmental stimuli. One putative mechanism of control is the desynchronization of electroencephalography (EEG) alpha rhythms (similar to 8-12 Hz) in visual cortex in anticipation of a visual target. We show that brief interference by repetitive transcranial magnetic stimulation (rTMS) with preparatory activity in right IPS or right FEF while subjects attend to a spatial location impairs identification of target visual stimuli similar to 2 s later. This behavioral effect is associated with the disruption of anticipatory (prestimulus) alpha desynchronization and its spatially selective topography in parieto-occipital cortex. Finally, the disruption of anticipatory alpha rhythms in occipital cortex after right IPS- or right FEF-rTMS correlates with deficits of visual identification. These results support the causal role of the dorsal frontoparietal network in the control of visuospatial attention, and suggest that this is partly exerted through the synchronization of occipital visual neurons.

引用

页码：5863 / 5872

页数：10

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