Hydrogels for oral delivery of therapeutic proteins

被引：133

作者：

Peppas, NA ^{[1
]}

Wood, KM

Blanchette, JO

机构：

[1] Univ Texas, Dept Chem, Lab Biomat Drug Delivery Bionanotechnol & Mol Rec, Austin, TX 78712 USA

[2] Univ Texas, Dept Biomed Engn, Lab Biomat Drug Delivery Bionanotechnol & Mol Rec, Austin, TX 78712 USA

[3] Univ Texas, Div Pharmaceut, Austin, TX 78712 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2004年 / 4卷 / 06期

关键词：

bioavailability; drug delivery; hydrogel; insulin; intelligent biomaterial; long-term stability; protein;

D O I：

10.1517/14712598.4.6.881

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

In recent years there has been significant new interest in the development of transmucosal (mostly oral) pharmaceutical formulations for the delivery of therapeutic proteins. Emphasis has been given to the molecular design of new carriers for the delivery of insulin, calcitonin and various types of interferons for the treatment of diabetes, osteoporosis, multiple sclerosis and cancer. Most popular carriers include advanced designs of swollen hydrogels prepared from neutral or intelligent polymeric networks. In this review, the most successful of such systems are presented and their promise in the field described.

引用

页码：881 / 887

页数：7

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