Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol

被引：241

作者：

Ochiai, T

Ohno, S

Soeda, S

Tanaka, H

Shoyama, Y

Shimeno, H

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Biochem, Jonan Ku, Fukuoka 814180, Japan

[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmacognosy, Higashi Ku, Fukuoka 8128582, Japan

来源：

NEUROSCIENCE LETTERS | 2004年 / 362卷 / 01期

关键词：

lipid peroxidation; superoxide dismutase; alpha-tocopherol; crocin; antioxidant; neuronal death; PC-12; cells;

D O I：

10.1016/j.neulet.2004.02.067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Crocin is a pharmacologically active component of Crocus sativus L. (saffron) used in traditional Chinese medicine. We report here the effects of crocin on neuronally differentiated pheochromocytoma (PC-12) cells deprived of serum/glucose. Depriving the PC-12 cells of serum/glucose caused peroxidation of their cell membrane lipids and decreased intercellular superoxide dismutase (SOD) activity. Treating the PC-12 cells with 10 muM crocin inhibited the formation of peroxidized lipids, partly restored the SOD activity, and maintained the neuron's morphology. These antioxidant effects of crocin were more effective than those of a-tocopherol at the same concentration. Crocin also suppressed the activation of caspase-8 caused by serum/glucose deprivation. These results together with our previous data suggest that crocin is a unique and potent antioxidant that combats oxidative stress in neurons. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

共 14 条

[1]

Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis [J].