Potassium channels Brief overview and implications in epilepsy

被引:34
作者
Benarroch, Eduardo E. [1 ]
机构
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
关键词
VOLTAGE-GATED POTASSIUM; UNION-OF-PHARMACOLOGY; INTERNATIONAL-UNION; MOLECULAR RELATIONSHIPS; DEND-SYNDROME; KCNQ3; MUTATIONS; ION CHANNELS; NOMENCLATURE; SEIZURES; BRAIN;
D O I
10.1212/01.wnl.0000343739.72081.4e
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:664 / 669
页数:6
相关论文
共 32 条
[21]   Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures [J].
Porter, R. J. ;
Partiot, A. ;
Sachdeo, R. ;
Nohria, V. ;
Alves, W. M. .
NEUROLOGY, 2007, 68 (15) :1197-1204
[22]   Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome [J].
Proks, Peter ;
Shimomura, Kenju ;
Craig, Tim J. ;
de Wet, Heidi ;
Girard, Christophe A. J. ;
Ashcroft, Frances M. .
HUMAN MOLECULAR GENETICS, 2007, 16 (16) :2011-2019
[23]   Variable K+ channel subunit dysfunction in inherited mutations of KCNA1 [J].
Rea, R ;
Spauschus, A ;
Eunson, LH ;
Hanna, MG ;
Kullmann, DM .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 538 (01) :5-23
[24]   The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvβ1 [J].
Schulte, U ;
Thumfart, JO ;
Klöcker, N ;
Sailer, CA ;
Blidl, W ;
Biniossek, M ;
Dehn, D ;
Deller, T ;
Eble, S ;
Abbass, K ;
Wangler, T ;
Knaus, HG ;
Fakler, B .
NEURON, 2006, 49 (05) :697-706
[25]  
Shieh CC, 2000, PHARMACOL REV, V52, P557
[26]   A novel mutation causing DEND syndrome -: A treatable channelopathy of pancreas and brain [J].
Shimomura, K. ;
Hoerster, F. ;
de Wet, H. ;
Flanagan, S. E. ;
Ellard, S. ;
Hattersley, A. T. ;
Wolf, N. I. ;
Ashcroft, F. ;
Ebinger, F. .
NEUROLOGY, 2007, 69 (13) :1342-1349
[27]   Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization [J].
Singh, Nanda A. ;
Otto, James F. ;
Dahle, E. Jill ;
Pappas, Chris ;
Leslie, Jonathan D. ;
Vilaythong, Alex ;
Noebels, Jeffrey L. ;
White, H. Steve ;
Wilcox, Karen S. ;
Leppert, Mark F. .
JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (14) :3405-3423
[28]   Deletion of the Kv1.1 potassium channel causes epilepsy in mice [J].
Smart, SL ;
Lopantsev, V ;
Zhang, CL ;
Robbins, CA ;
Wang, H ;
Chiu, SY ;
Schwartzkroin, PA ;
Messing, A ;
Tempel, BL .
NEURON, 1998, 20 (04) :809-819
[29]   Clinical spectrum of voltage-gated potassium channel autoimmunity [J].
Tan, K. M. ;
Lennon, V. A. ;
Klein, C. J. ;
Boeve, B. F. ;
Pittock, S. J. .
NEUROLOGY, 2008, 70 (20) :1883-1890
[30]   Localization of voltage-gated ion channels in mammalian brain [J].
Trimmer, JS ;
Rhodes, KJ .
ANNUAL REVIEW OF PHYSIOLOGY, 2004, 66 :477-519