Recent developments in liver pathology

被引：5

作者：

Lefkowitch, Jay H. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

来源：

HUMAN PATHOLOGY | 2009年 / 40卷 / 04期

关键词：

Liver; Liver biopsy; Fatty liver; Liver tumors; Glypican-3; Iron; Mallory-Denk body; HEPATITIS-E VIRUS; PLASMA-CELL HEPATITIS; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; GLYPICAN-3; EXPRESSION; AUTOIMMUNE HEPATITIS; CENTRAL PERIVENULITIS; CENTRAL VENULITIS; PROGENITOR CELLS; NATURAL-HISTORY;

D O I：

10.1016/j.humpath.2008.12.014

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Progress in liver histopathology continues to be made, as evidenced by recent publications in all areas of hepatobiliary disease. Multinucleated giant hepatocytes, known to be associated with autoimmune and drug hepatitis, now have been seen in chronic hepatitis C with or without HIV infection and in patients with infection by human herpesvirus-6A. The new term Mallory-Denk body (formerly the Mallory body) recognizes the substantial contributions to this field by Prfessor Helmut Denk of Austria. The problems of fatly liver and hepatic iron overload have been addressed ill Studies highlighting their complex pathogenesis. Genomic and immunohistochemical analysis of liver tumors provides important diagnostic information, particularly regarding the use of glypican-3 in the diagnosis Of hepatocellular carcinoma. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：445 / 455

页数：11

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