Microfluidic technologies for yeast replicative lifespan studies

被引：45

作者：

Chen, Kenneth L. ^{[1
,2
,3
]}

Crane, Matthew M. ^{[1
]}

Kaeberlein, Matt ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

[3] Univ Washington, Med Scientist Training Program, Seattle, WA 98195 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2017年 / 161卷

关键词：

Yeast; Microfluidics; Microscopy; Replicative aging; Microdissection; Lifespan; GENE-EXPRESSION; DAUGHTER CELLS; BUDDING YEAST; SACCHAROMYCES-CEREVISIAE; MITOCHONDRIAL-FUNCTION; EXTENSION; IDENTIFICATION; DETERMINANTS; RESTRICTION; DYNAMICS;

D O I：

10.1016/j.mad.2016.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The budding yeast Saccharomyces cerevisiae has been used as a model organism for the study of aging for over 50 years. In this time, the canonical aging experiment replicative lifespan analysis by manual microdissection has remained essentially unchanged. Recently, microfluidic technologies have been developed that may be able to substitute for this time- and labor-intensive procedure. These technologies also allow cell physiology to be observed throughout the entire lifetime. Here, we review these devices, novel observations they have made possible, and some of the current system limitations. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：262 / 269

页数：8

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