Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

被引：48

作者：

Delaney, Joe R. ^{[1
,2
]}

Murakami, Christopher ^{[1
]}

Chou, Annie ^{[1
]}

Carr, Daniel ^{[1
]}

Schleit, Jennifer ^{[1
]}

Sutphin, George L. ^{[1
,2
]}

An, Elroy H. ^{[1
]}

Castanza, Anthony S. ^{[1
]}

Fletcher, Marissa ^{[1
]}

Goswami, Sarani ^{[1
]}

Higgins, Sean ^{[1
]}

Holmberg, Mollie ^{[1
]}

Hui, Jessica ^{[1
]}

Jelic, Monika ^{[1
]}

Jeong, Ki-Soo ^{[1
]}

Kim, Jin R. ^{[1
]}

Klum, Shannon ^{[1
]}

Liao, Eric ^{[1
]}

Lin, Michael S. ^{[1
]}

Lo, Winston ^{[1
]}

Miller, Hillary ^{[1
]}

Moller, Richard ^{[1
]}

Peng, Zhao J. ^{[1
]}

Pollard, Tom ^{[1
]}

Pradeep, Prarthana ^{[1
]}

Pruett, Dillon ^{[1
]}

Rai, Dilreet ^{[1
]}

Ros, Vanessa ^{[1
]}

Schuster, Alex ^{[1
]}

Singh, Minnie ^{[1
]}

Spector, Benjamin L. ^{[1
]}

Wende, Helen Vander ^{[1
]}

Wang, Adrienne M. ^{[1
]}

Wasko, Brian M. ^{[1
]}

Olsen, Brady ^{[1
]}

Kaeberlein, Matt ^{[1
,3
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA

[3] Guangdong Med Coll, Inst Aging Res, Dongguan 523808, Peoples R China

来源：

EXPERIMENTAL GERONTOLOGY | 2013年 / 48卷 / 10期

关键词：

Chronological lifespan; Replicative lifespan; Caloric restriction; Calorie restriction; Dietary restriction; Glucose; Mitochondria; LIFE-SPAN; CALORIE RESTRICTION; DAMAGED PROTEINS; AGE ASYMMETRY; YEAST; LONGEVITY; EXTENSION; EXTENDS; SIR2; MOTHER;

D O I：

10.1016/j.exger.2012.12.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23 days of chronological age. We further show that among the viable portion of the control population aged 26 days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1006 / 1013

页数：8

共 44 条

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Asymmetric inheritance of oxidatively damaged proteins during cytokinesis [J].