This study extends a line of programmatic research on families who decline participation in intervention and assessment components of family-focused prevention projects. Parents responding to a brief telephone interview (N = 459) identified the most important of 28 barriers concerning project assessments, intervention-related time demands and logistic requirements, beliefs and attitudes about interventions and family member influences. Results demonstrated that several time-related factors, logistic requirements, and family member influences were important barriers Findings also showed that sociodemographic factors were associated with unfavorable attitudes about interventions and their assessments. Implications for the development of effective recruitment strategies and for future research are presented.