Update on strategies to increase HDL quantity and function

被引：155

作者：

Duffy, Danielle ^{[2
]}

Rader, Daniel J. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA

[2] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA

来源：

NATURE REVIEWS CARDIOLOGY | 2009年 / 6卷 / 07期

关键词：

ESTER TRANSFER PROTEIN; REVERSE CHOLESTEROL TRANSPORT; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; EXTENDED-RELEASE NIACIN; PPAR-ALPHA AGONIST; NICOTINIC-ACID; ENDOTHELIAL LIPASE; MOLECULAR-IDENTIFICATION; CORONARY ATHEROSCLEROSIS;

D O I：

10.1038/nrcardio.2009.94

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Low levels of HDL cholesterol are a significant predictor of atherosclerotic cardiovascular events. HDL is believed to protect against atherosclerosis by promoting reverse cholesterol transport, and potentially through anti-inflammatory, antioxidative, antithrombotic and nitric oxide effects. The multiple mechanisms of action, as well as a limited ability to measure these properties, make HDL a complex therapeutic target, albeit one with immense potential for the treatment of patients with atherosclerosis. Here, we discuss new therapeutic strategies currently being developed, which have the potential to increase plasma levels of HDL cholesterol and/or improve HDL function.

引用

页码：455 / 463

页数：9

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