ROLE OF MITOCHONDRIA IN NEURODEGENERATIVE DISEASES: MITOCHONDRIA AS A THERAPEUTIC TARGET IN ALZHEIMER'S DISEASE

被引：141

作者：

Reddy, P. Hemachandra ^{[1
]}

机构：

[1] Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR USA

来源：

CNS SPECTRUMS | 2009年 / 14卷 / 08期

关键词：

AMYLOID PRECURSOR PROTEIN; CYTOCHROME-C-OXIDASE; OXIDATIVE DAMAGE; GENE-EXPRESSION; DYSFUNCTION; BETA; BRAIN; ABNORMALITIES; ACCUMULATION; MUTATIONS;

D O I：

10.1017/S1092852900024901

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：8 / 13

页数：6

共 41 条

[1] Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
Anandatheerthavarada, HK
Biswas, G
Robin, MA
Avadhani, NG
[J]. JOURNAL OF CELL BIOLOGY, 2003, 161 (01) : 41 - 54
[2] SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME
ANDERSON, S
BANKIER, AT
BARRELL, BG
DEBRUIJN, MHL
COULSON, AR
DROUIN, J
EPERON, IC
NIERLICH, DP
ROE, BA
SANGER, F
SCHREIER, PH
SMITH, AJH
STADEN, R
YOUNG, IG
[J]. NATURE, 1981, 290 (5806) : 457 - 465
[3] Mitochondria take center stage in aging and neurodegeneration
Beal, MF
[J]. ANNALS OF NEUROLOGY, 2005, 58 (04) : 495 - 505
[4] Mitochondrial Aβ:: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C
Wang, N
Yao, J
Sosunov, A
Chen, X
Lustbader, JW
Xu, HW
Stern, D
McKhann, G
Yan, SD
[J]. FASEB JOURNAL, 2005, 19 (12) : 2040 - +
[5] IMPAIRMENT IN MITOCHONDRIAL CYTOCHROME-OXIDASE GENE-EXPRESSION IN ALZHEIMER-DISEASE
CHANDRASEKARAN, K
GIORDANO, T
BRADY, DR
STOLL, J
MARTIN, LJ
RAPOPORT, SI
[J]. MOLECULAR BRAIN RESEARCH, 1994, 24 (1-4): : 336 - 340
[6] Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
Coskun, PE
Beal, MF
Wallace, DC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) : 10726 - 10731
[7] Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-β1-42
Crouch, PJ
Blake, R
Duce, JA
Ciccotosto, GD
Li, QX
Barnham, KJ
Curtain, CC
Cherny, RA
Cappai, R
Dyrks, T
Masters, CL
Trounce, IA
[J]. JOURNAL OF NEUROSCIENCE, 2005, 25 (03) : 672 - 679
[8] Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Devi, Latha
Prabhu, Badanavalu M.
Galati, Domenico F.
Avadhani, Narayan G.
Anandatheerthavarada, Hindupur K.
[J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (35) : 9057 - 9068
[9] Mitochondrial disorders in the nervous system
DiMauro, Salvatore
Schon, Eric A.
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 2008, 31 : 91 - 123
[10] DOODY RS, LANCET, V372, P207

← 1 2 3 4 5 →