Asymmetric total syntheses of Ecteinascidin 597 and Ecteinascidin 583

被引：39

作者：

Chen, Jinchun ^{[1
]}

Chen, Xiaochuan ^{[1
]}

Willot, Matthieu ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 47期

关键词：

alkaloids; antitumor agents; asymmetric synthesis; marine natural products; Pictet-Spengler reaction;

D O I：

10.1002/anie.200603179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The limited availability of bioactive natural products for pharmaceutical studies and drug development is a problem that can be solved, in principle, by total synthesis. The potent antitumor marine natural products ecteinascidin 597 (1) and ecteinascidin 583 (2) have now been synthesized from readily accessible starting materials in a highly convergent and stereoselective fashion (see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8028 / 8032

页数：5

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