Synthesis of ecteinascidin 743 analogues from cyanosafracin B:: Isolation of a kinetically stable quinoneimine tautomer of a 5-hydroxyindole

被引：18

作者：

Ceballos, PA ^{[1
]}

Pérez, M

Cuevas, C

Francesch, A

Manzanares, I

Echavarren, AM

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, Madrid 28049, Spain

[2] PharmaMar, Madrid, Spain

[3] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 08期

关键词：

quinones; indoles; tautomerism; antitumor agents; natural products;

D O I：

10.1002/ejoc.200500882

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phthalimido derivatives of cyanosafracin B have been synthesized as analogues of the antitumor agent ectemascidin 743. As part of this study, a quinoneimine has been prepared, which is a kinetically stable tautomer of a 5-hydroxyin dole. This quinoneimine tautomer is stable under acidic and mild basic conditions. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).

引用

页码：1926 / 1933

页数：8

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