High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

被引：24

作者：

Galili, U

Minanov, OP

Michler, RE

Stone, KR

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,DIV CARDIOTHORAC SURG,NEW YORK,NY 10032

[2] STONE CLIN,SAN FRANCISCO,CA

来源：

XENOTRANSPLANTATION | 1997年 / 4卷 / 03期

关键词：

xenotransplantation; anti-Gal; xenoreactive antibodies;

D O I：

10.1111/j.1399-3089.1997.tb00175.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The immune system in humans and monkeys responds vigorously against alpha-gal (alpha-galactosyl, Gal alpha 1-3Gal beta 1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent eel cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

引用

页码：127 / 131

页数：5

共 27 条

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