Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy

被引：58

作者：

Aronsson, F ^{[1
]}

Lannebo, C ^{[1
]}

Paucar, M ^{[1
]}

Brask, J ^{[1
]}

Kristensson, K ^{[1
]}

Karlsson, H ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

来源：

JOURNAL OF NEUROVIROLOGY | 2002年 / 8卷 / 04期

关键词：

orthomyxoviridae; central nervous system; persistent infection; placenta; in utero;

D O I：

10.1080/13550280290100480

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood.

引用

页码：353 / 357

页数：5

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