Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

被引：415

作者：

Mattson, MP ^{[1
]}

LaFerla, FM

Chan, SL

Leissring, MA

Shepel, PN

Geiger, JD

机构：

[1] NIA, Neurosci Lab, Baltimore, MD 21224 USA

[2] Univ Calif Irvine, Lab Mol Neuropathogenesis, Dept Neurobiol & Behav, Irvine, CA 92697 USA

[3] Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0W3, Canada

来源：

TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0166-2236(00)01548-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endoplasmic reticulum (ER) is a multifaceted organelle that regulates protein synthesis and trafficking, cellular responses to stress. and intracellular Ca2+ levels. In neurons, it is distributed, between the cellular compartments that regulate plasticity and survival, which include axons, dendrites, growth cones and synaptic terminals. Intriguing communication networks between ER, mitochondria and plasma membrane are being revealed that provide mechanisms for the precise regulation of temporal and spatial aspects of Ca2+ signaling. Alterations in Ca2+ homeostasis in ER contribute to neuronal apoptosis and excitotoxicity, and are being linked to the pathogenesis of several different neurodegenerative disorders, including Alzheimer's disease and stroke.

引用

页码：222 / 229

页数：8

共 88 条

[11] Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [J].