Genetic determinants of mammographic density

被引:63
作者
Haiman, CA [1 ]
Bernstein, L
Van Den Berg, D
Ingles, SA
Salane, M
Ursin, G
机构
[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
[2] MSW Consulting, Bloomfield Hills, MI USA
关键词
breast cancer; genetic susceptibility; mammographic density; molecular epidemiology;
D O I
10.1186/bcr434
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Changes in breast density are highly correlated with steroid hormone exposure. Materials and methods: In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymorphisms in genes involved in steroid hormone biosynthesis and metabolism, CYP17 (T27C), COMT (Val158Met), 17HSDB1 (Ser312Gly) and 3HSDB1 (Asn367Thr), predict mammographic density. We also evaluated whether associations vary by menopausal and hormone replacement therapy status. Results: We found no strong consistent relationships between polymorphisms in these genes and breast density. African-American women homozygous for the Thr allele of 3HSDB1 had increased density (the absolute difference versus the Asn/Asn genotype was +19.7%; P trend = 0.02), while Caucasian homozygous women had decreased density (-5.1%; P trend = 0.04). Among premenopausal women, carriers of the Ser allele had (not significantly) greater density (versus Gly/Gly genotype: +7.1%; P trend = 0.07). In addition, among current users of hormone replacement therapy, we observed that women with the low-activity Met/Met genotype of COMT had greater breast density (versus the Val/Val genotype: +11.7%; P trend = 0.01). Conclusion: Additional large studies evaluating these and other candidate breast cancer genes will be required to determine what proportion, if any, of the interindividual differences in breast density are due to underlying genetic variation in genes involved in steroid hormone biosynthesis or metabolism.
引用
收藏
页数:6
相关论文
共 30 条
[11]   Effects of estrogen and estrogen-progestin on mammographic parenchymal density [J].
Greendale, GA ;
Reboussin, BA ;
Sie, A ;
Singh, HR ;
Olson, LK ;
Gatewood, O ;
Bassett, LW ;
Wasilauskas, C ;
Bush, T ;
Barrett-Connor, E .
ANNALS OF INTERNAL MEDICINE, 1999, 130 (04) :262-+
[12]   FACTORS ASSOCIATED WITH MAMMOGRAPHIC PATTERN [J].
GROVE, JS ;
GOODMAN, MJ ;
GILBERT, FI ;
MI, MP .
BRITISH JOURNAL OF RADIOLOGY, 1985, 58 (685) :21-25
[13]  
Haiman CA, 1999, CANCER RES, V59, P1015
[14]  
Haiman CA, 2001, CANCER RES, V61, P3955
[15]  
Lavigne JA, 1997, CANCER RES, V57, P5493
[16]   EFFECT OF POSTMENOPAUSAL HORMONAL REPLACEMENT THERAPY ON MAMMOGRAPHIC DENSITY AND PARENCHYMAL PATTERN [J].
LAYA, MB ;
GALLAGHER, JC ;
SCHREIMAN, JS ;
LARSON, EB ;
WATSON, P ;
WEINSTEIN, L .
RADIOLOGY, 1995, 196 (02) :433-437
[17]   Allelic discrimination using fluorogenic probes and the 5′ nuclease assay [J].
Livak, KJ .
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1999, 14 (5-6) :143-149
[18]   HUMAN FAMILIAL AND SPORADIC BREAST-CANCER - ANALYSIS OF THE CODING REGIONS OF THE 17-BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE (EDH17B2) USING A SINGLE-STRAND CONFORMATION POLYMORPHISM ASSAY [J].
MANNERMAA, A ;
PELTOKETO, H ;
WINQVIST, R ;
PONDER, BAJ ;
KIVINIEMI, H ;
EASTON, DF ;
POUTANEN, M ;
ISOMAA, V ;
VIHKO, R .
HUMAN GENETICS, 1994, 93 (03) :319-324
[19]  
MARCHBANKS PA, IN PRESS ANN EPIDEMI
[20]   Catechol-O-methyltransferase and breast cancer risk [J].
Millikan, RC ;
Pittman, GS ;
Tse, CKJ ;
Duell, E ;
Newman, B ;
Savitz, D ;
Moorman, PG ;
Boissy, RJ ;
Bell, DA .
CARCINOGENESIS, 1998, 19 (11) :1943-1947