Zinc-dependent protein folding

被引：137

作者：

Cox, EH ^{[1
]}

McLendon, GL

机构：

[1] Princeton Univ, Ctr Environm Bioinorgan Chem, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Geosci, Princeton, NJ 08544 USA

[3] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(99)00070-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of classic zinc-finger peptides over the past 15 years have offered insights into the coupled processes of metal binding and protein folding. Within the past two years, this insight has been used to increase our understanding of the importance of first and second shell contributions (i.e. contributions from direct and indirect metal ligands) to metal binding and protein-folding stability, and led to advances in de novo protein design and protein redesign.

引用

页码：162 / 165

页数：4

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