Automated model-based tissue classification of MR images of the brain

被引:838
作者
Van Leemput, K
Maes, F
Vandermeulen, D
Suetens, P
机构
[1] Univ Hosp Gasthuisberg, Fac Med, B-3000 Louvain, Belgium
[2] Univ Hosp Gasthuisberg, Fac Engn, B-3000 Louvain, Belgium
关键词
digital brain atlas; Markov random fields; MRI; segmentation; tissue classification;
D O I
10.1109/42.811270
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
We describe a fully automated method for model-based tissue classification of magnetic resonance (MR) images of the brain, The method interleaves classification with estimation of the model parameters, improving the classification at each iteration. The algorithm is able to segment single- and multispectral MR images, corrects for MR signal inhomogeneities, and incorporates contextual information by means of Markov random Fields (MRF's). A digital brain atlas containing prior expectations about the spatial location of tissue classes is used to initialize the algorithm. This makes the method fully automated and therefore it provides objective and reproducible segmentations, We have validated the technique on simulated as well as on real MR images of the brain.
引用
收藏
页码:897 / 908
页数:12
相关论文
共 31 条
[1]  
[Anonymous], MATL
[2]  
ASHBURNER J, STAT PARAMETRIC MAPP
[3]  
BESAG J, 1986, J R STAT SOC B, V48, P259
[4]   PARTIAL VOLUME TISSUE CLASSIFICATION OF MULTICHANNEL MAGNETIC-RESONANCE IMAGES - A MIXEL MODEL [J].
CHOI, HS ;
HAYNOR, DR ;
KIM, YM .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1991, 10 (03) :395-407
[5]  
Cocosco CA., 1997, NEUROIMAGE, V5, pS425, DOI DOI 10.1016/S1053-8119(97)80018-3
[6]   Design and construction of a realistic digital brain phantom [J].
Collins, DL ;
Zijdenbos, AP ;
Kollokian, V ;
Sled, JG ;
Kabani, NJ ;
Holmes, CJ ;
Evans, AC .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1998, 17 (03) :463-468
[7]   MAXIMUM LIKELIHOOD FROM INCOMPLETE DATA VIA EM ALGORITHM [J].
DEMPSTER, AP ;
LAIRD, NM ;
RUBIN, DB .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL, 1977, 39 (01) :1-38
[8]  
Descombes X., 1995, P 9 SCIA 95 UPPS SWE, P349
[9]   MEASURES OF THE AMOUNT OF ECOLOGIC ASSOCIATION BETWEEN SPECIES [J].
DICE, LR .
ECOLOGY, 1945, 26 (03) :297-302
[10]   Markov random field segmentation of brain MR images [J].
Held, K ;
Kops, ER ;
Krause, BJ ;
Wells, WM ;
Kikinis, R ;
Muller-Gartner, HW .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 1997, 16 (06) :878-886