Hippocampal cholinergic blockade enhances hypothalamic-pituitary-adrenal responses to stress

被引：35

作者：

Bhatnagar, S ^{[1
]}

Costall, B ^{[1
]}

Smythe, JW ^{[1
]}

机构：

[1] UNIV BRADFORD,DEPT PHARMACOL,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND

来源：

BRAIN RESEARCH | 1997年 / 766卷 / 1-2期

关键词：

hippocampus; cholinergic; stress; adrenocorticotropin; corticosterone; theta; fear;

D O I：

10.1016/S0006-8993(97)00684-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the role of the hippocampal cholinergic system, which is known to mediate processes related to fear and anxiety, in the regulation of stress-induced hypothalamic-pituitary-adrenal (HPA) activity. Bilateral intra-hippocampal injections (30 CLS per side) of the muscarinic antagonist Scopolamine augmented adrenocorticotropin and corticosterone responses to restraint without altering basal HPA activity compared to vehicle-treated animals. These results suggest that the hippocampal cholinergic system regulates stress-induced HPA activity and may serve to coordinate behavioral and neuroendocrine responses to stress. (C) 1997 Elsevier Science B.V.

引用

页码：244 / 248

页数：5

共 27 条

[11] BIOCHEMICAL INDEXES OF REACTIVITY AND HABITUATION IN RATS WITH HIPPOCAMPAL-LESIONS [J].

KANT, GJ ;

MEYERHOFF, JL ;

JARRARD, LE .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 20 (05) :793-797

[12] 2 TYPES OF HIPPOCAMPAL RHYTHMICAL SLOW ACTIVITY IN BOTH RABBIT AND RAT - RELATIONS TO BEHAVIOR AND EFFECTS OF ATROPINE, DIETHYL-ETHER, URETHANE, AND PENTOBARBITAL [J].

KRAMIS, R ;

VANDERWOLF, CH ;

BLAND, BH .

EXPERIMENTAL NEUROLOGY, 1975, 49 (01) :58-85

[13] SURGICAL DISCONNECTION OF MEDIAL BASAL HYPOTHALAMUS AND PITUITARY-FUNCTION IN RHESUS-MONKEY .2. GH AND CORTISOL SECRETION [J].

KREY, LC ;

LU, KH ;

BUTLER, WR ;

HOTCHKISS, J ;

PIVA, F ;

KNOBIL, E .

ENDOCRINOLOGY, 1975, 96 (05) :1088-1093

[14] THE ROLE OF THE SEPTOHIPPOCAMPAL PATHWAY IN THE REGULATION OF HIPPOCAMPAL FIELD ACTIVITY AND BEHAVIOR - ANALYSIS BY THE INTRASEPTAL MICROINFUSION OF CARBACHOL, ATROPINE, AND PROCAINE [J].

LAWSON, VH ;

BLAND, BH .

EXPERIMENTAL NEUROLOGY, 1993, 120 (01) :132-144

[15] GLUCOCORTICOID NEGATIVE FEEDBACK AND GLUCOCORTICOID RECEPTORS AFTER HIPPOCAMPECTOMY IN RATS [J].

MAGARINOS, AM ;

SOMOZA, G ;

DENICOLA, AF .

HORMONE AND METABOLIC RESEARCH, 1987, 19 (03) :105-109

[16] ACETYLCHOLINE-RELEASE IN THE RAT HIPPOCAMPUS AS MEASURED BY THE MICRODIALYSIS METHOD CORRELATES WITH MOTOR-ACTIVITY AND EXHIBITS A DIURNAL-VARIATION [J].

MIZUNO, T ;

ENDO, Y ;

ARITA, J ;

KIMURA, F .

NEUROSCIENCE, 1991, 44 (03) :607-612

[17] EFFECT OF SECTIONING FORNIX ON DIURNAL FLUCTUATION IN PLASMA CORTICOSTERONE LEVELS IN RAT [J].

MOBERG, GP ;

SCAPAGNINI, U ;

DEGROOT, J ;

GANONG, WF .

NEUROENDOCRINOLOGY, 1971, 7 (01) :11-+

[18] ACETYLCHOLINE-RELEASE IN THE RAT HIPPOCAMPUS AS STUDIED BY MICRODIALYSIS IS DEPENDENT ON AXONAL IMPULSE FLOW AND INCREASES DURING BEHAVIORAL ACTIVATION [J].

NILSSON, OG ;

KALEN, P ;

ROSENGREN, E ;

BJORKLUND, A .

NEUROSCIENCE, 1990, 36 (02) :325-338

[19] ELEVATION OF HYPOPHYSEAL PORTAL CONCENTRATIONS OF ADRENOCORTICOTROPIN SECRETAGOGUES AFTER FORNIX TRANSECTION [J].

SAPOLSKY, RM ;

ARMANINI, MP ;

SUTTON, SW ;

PLOTSKY, PM .

ENDOCRINOLOGY, 1989, 125 (06) :2881-2887

[20]

SAPOLSKY RM, 1991, J NEUROSCI, V11, P3695

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