Chronology versus biology - Telomeres, essential hypertension, and vascular aging

被引：61

作者：

Aviv, A ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Hypertens Res Ctr, Newark, NJ 07103 USA

来源：

HYPERTENSION | 2002年 / 40卷 / 03期

关键词：

hypertension; essential; aging; genetics; oxidative stress; cardiovascular diseases;

D O I：

10.1161/01.HYP.0000027280.91984.1B

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

There is considerable evidence that essential hypertension is closely linked to the growth, development, and aging of human beings. It is imperative, therefore, to introduce biological indicators of growth and aging into models developed to provide a better understanding of the etiology of essential hypertension. One of these indicators may well be the age-dependent telomere attrition rate in somatic cells. Telomere attrition registers the replicative history of somatic cells. As such, it chronicles not only the growth that results from the replication of somatic cells but also their turnover-a process that is strongly linked to inflammation and oxidative stress, which are key factors in the biology of human aging.

引用

页码：229 / 232

页数：4

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