Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties

被引：49

作者：

Bettum, Ingrid J. ^{[1
]}

Vasiliauskaite, Kotryna ^{[1
]}

Nygaard, Vigdis ^{[1
]}

Clancy, Trevor ^{[1
]}

Pettersen, Solveig J. ^{[1
]}

Tenstad, Ellen ^{[1
,2
]}

Maelandsmo, Gunhild M. ^{[1
,3
]}

Prasmickaite, Lina ^{[1
]}

机构：

[1] Oslo Univ Hosp, Div Canc Surg & Transplantat, Inst Canc Res, Dept Tumor Biol, N-0310 Oslo, Norway

[2] Univ Oslo, Fac Med, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, Oslo, Norway

[3] Univ Tromso, Fac Hlth Sci, Inst Pharm, Tromso, Norway

来源：

CANCER LETTERS | 2014年 / 344卷 / 01期

关键词：

S100A4; Tumor-stroma interactions; Metastasis; Cytokines; Melanoma; EXTRACELLULAR S100A4; TUMOR; INTERLEUKIN-8; PROGRESSION; EXPRESSION; PHENOTYPE; MONOCYTES; LACKING; GROWTH; NICHE;

D O I：

10.1016/j.canlet.2013.10.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tumor cells have the ability to exploit stromal cells to facilitate metastasis. By using malignant melanoma as a model, we show that the stroma adjacent to metastatic lesions is enriched in the known metastasis-promoting protein S100A4. S100A4 stimulates cancer cells to secrete paracrine factors, such as inflammatory cytokines 18, CCL2 and SAA, which activate stromal cells (endothelial cells and monocytes) so that they acquire tumor-supportive properties. Our data establishes S1 00A4 as an inducer of a cytokine network enabling tumor cells to engage angiogenic and inflammatory stromal cells, which might contribute to pro-metastatic activity of S100A4. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：28 / 39

页数：12

相关论文

共 54 条

[1]

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis [J].

Acharyya, Swarnali ;

Oskarsson, Thordur ;

Vanharanta, Sakari ;

Malladi, Srinivas ;

Kim, Juliet ;

Morris, Patrick G. ;

Manova-Todorova, Katia ;

Leversha, Margaret ;

Hogg, Nancy ;

Seshan, Venkatraman E. ;

Norton, Larry ;

Brogi, Edi ;

Massague, Joan .

CELL, 2012, 150 (01) :165-178

[2]

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor [J].

Ambartsumian, N ;

Klingelhöfer, J ;

Grigorian, M ;

Christensen, C ;

Kriajevska, M ;

Tulchinsky, E ;

Georgiev, G ;

Berezin, V ;

Bock, E ;

Rygaard, J ;

Cao, RH ;

Cao, YH ;

Lukanidin, E .

ONCOGENE, 2001, 20 (34) :4685-4695

[3]

Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma [J].

Andersen, K ;

Nesland, JM ;

Holm, R ;

Florenes, VA ;

Fodstad, O ;

Mælandsmo, GM .

MODERN PATHOLOGY, 2004, 17 (08) :990-997

[4]

Role of interleukin-8 in tumor growth and metastasis of human melanoma [J].

Bar-Eli, M .

PATHOBIOLOGY, 1999, 67 (01) :12-18

[5]

Osteopontin-an important downstream effector of S100A4-mediated invasion and metastasis [J].

Berge, Gisle ;

Pettersen, Solveig ;

Grotterod, Ida ;

Bettum, Ingrid J. ;

Boye, Kjetil ;

Maelandsmo, Gunhild M. .

INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (04) :780-790

[6]

Activation of NF-κB by extracellular S100A4:: Analysis of signal transduction mechanisms and identification of target genes [J].

Boye, Kjetil ;

Grotterod, Ida ;

Aasheim, Hans-Christian ;

Hovig, Eivind ;

Maelandsmo, Gunhild M. .

INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (06) :1301-1310

[7]

S100A4 and Metastasis A Small Actor Playing Many Roles [J].

Boye, Kjetil ;

Maelandsmo, Gunhild M. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (02) :528-535

[8]

Expression of S100A4 by, a variety of cell types present in the tumor microenvironment of human breast cancer [J].

Cabezon, Teresa ;

Celis, Julio E. ;

Skibshoj, Inge ;

Klingelhofer, Jorg ;

Grigorian, Mariam ;

Gromov, Pavel ;

Rank, Fritz ;

Myklebust, June Helen ;

Maelandsmo, Gunhild M. ;

Lukanidin, Eugene ;

Ambartsumian, Noona .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (07) :1433-1444

[9]

The Vascular Basement Membrane as "Soil'' in Brain Metastasis [J].

Carbonell, W. Shawn ;

Ansorge, Olaf ;

Sibson, Nicola ;

Muschel, Ruth .

PLOS ONE, 2009, 4 (06)

[10]

Species-Specific In vivo Engraftment of the Human BL Melanoma Cell Line Results in an Invasive Dedifferentiated Phenotype Not Present in Xenografts [J].

Cedervall, Jessica ;

Jamil, Seema ;

Prasmickaite, Lina ;

Cheng, Yenfu ;

Eskandarpour, Malihe ;

Hansson, Johan ;

Maelandsmo, Gunhild M. ;

Ringborg, Ulrik ;

Gulyas, Miklos ;

Zhen, He Suo ;

Kanter, Lena ;

Ahrlund-Richter, Lars .

CANCER RESEARCH, 2009, 69 (09) :3746-3754

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