Advances in Coronary Microvascular Dysfunction

被引：52

作者：

Beltrame, John F. ^{[1
]}

Crea, Filippo ^{[2
]}

Camici, Paolo ^{[3
,4
]}

机构：

[1] Univ Adelaide, Cardiol Unit, Queen Elizabeth Hosp, Lyell McEwin Hlth Serv, Adelaide, SA, Australia

[2] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy

[3] Univ London Imperial Coll Sci Technol & Med, Ctr Clin Sci, London, England

[4] Univ London Imperial Coll Sci Technol & Med, NHLI, London, England

来源：

HEART LUNG AND CIRCULATION | 2009年 / 18卷 / 01期

关键词：

Microcirculation; Syndrome X; Coronary flow reserve; Coronary heart disease; MYOCARDIAL BLOOD-FLOW; CONVERTING ENZYME-INHIBITION; EXERCISE-INDUCED ANGINA; ST-SEGMENT DEPRESSION; CARDIAC SYNDROME-X; CHEST-PAIN; ARTERY-DISEASE; VASODILATOR RESERVE; PECTORIS; ISCHEMIA;

D O I：

10.1016/j.hlc.2008.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Considerable focus has been directed towards coronary arterial disease in the management of coronary heart disease, however the coronary microcirculation plays a major role in the regulation of coronary blood flow. Thus while we have multiple medical and revascularisation therapies to treat large vessel coronary artery disease, therapies directed towards the microcirculation are very limited. This review paper summarises important aspects of coronary microvascular dysfunction including (a) methods of assessment, (b) clinical classification of associated disorders, (c) possible pathophysiological mechanisms, and (d) potential therapies. Hence this will provide important background to advancing our understanding and management of coronary heart disease by targeting the coronary microcirculation.

引用

页码：19 / 27

页数：9

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