An approach to catalytic enantioselective protonation of prochiral lithium enolates

被引：45

作者：

Riviere, P ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] UNIV TOKYO,GRAD SCH PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4039(97)01790-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protonation of prochiral lithium enolates (4), prepared from racemic 2-substituted-1-tetralones (2) via their silyl enol ethers (3), with excess succinimide in the presence of lithium bromide and 0.2 equivalent of a chiral tetradentate amine ((R)-1) in toluene at -78 degrees C gave optically active 2 in up to 83% ee. (C) 1997 Elsevier Science Ltd.

引用

页码：7589 / 7592

页数：4

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