Inhibition of PI3K and MEK: It Is All about Combinations and Biomarkers

被引：33

作者：

Rexer, Brent N.

Ghosh, Ritwik

Arteaga, Carlos L. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Div Oncol, Dept Med, Nashville, TN 37232 USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 14期

关键词：

CANCER; MTOR; ACTIVATION;

D O I：

10.1158/1078-0432.CCR-09-0872

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A small molecule inhibitor of MAP/ERK kinase (MEK) was effective against human breast cancer cells with a basal-like gene expression signature. Antitumor activity was limited by both feedback upregulation of phosphatidylinositol-3 kinase (PI3K)/AKT upon inhibition of MEK as well as loss of the phosphatase PTEN. Therefore, MEK inhibitors should preferably be investigated in combination with PI3K inhibitors in basal-like breast cancers. (Clin Cancer Res 2009;15(14) July 2009).

引用

页码：4518 / 4520

页数：3

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