Nuclear organisation and gene expression

被引：46

作者：

Baxter, J ^{[1
]}

Merkenschlager, M ^{[1
]}

Fisher, AG ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Ctr Clin Sci,MRC,Lymphocyte Dev Grp, London W12 0NN, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(02)00339-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of increasingly sophisticated tools to track chromosomes and proteins in living cells offers the possibility of visualising gene regulation in the nucleus with minimal distortion. This, in conjunction with powerful genetic approaches available in yeast, is beginning to allow functional definition of nuclear 'compartments'.

引用

页码：372 / 376

页数：5

共 54 条

[1] Transcription sites are not correlated with chromosome territories in wheat nuclei [J].

Abranches, R ;

Beven, AF ;

Aragón-Alcaide, L ;

Shaw, PJ .

JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :5-12

[2] Perinuclear localization of chromatin facilitates transcriptional silencing [J].

Andrulis, ED ;

Neiman, AM ;

Zappulla, DC ;

Sternglanz, R .

NATURE, 1998, 394 (6693) :592-595

[3] Identification of a conserved erythroid specific domain of histone acetylation across the α-globin gene cluster [J].

Anguita, E ;

Johnson, CA ;

Wood, WG ;

Turner, BM ;

Higgs, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :12114-12119

[4] DNA methylation patterns and epigenetic memory [J].

Bird, A .

GENES & DEVELOPMENT, 2002, 16 (01) :6-21

[5] Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells [J].

Bix, M ;

Locksley, RM .

SCIENCE, 1998, 281 (5381) :1352-1354

[6]

Boveri T., 1909, ARCH EXP ZELLFORSCH, V3, P181

[7] Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts [J].

Bridger, JM ;

Boyle, S ;

Kill, IR ;

Bickmore, WA .

CURRENT BIOLOGY, 2000, 10 (03) :149-152

[8] Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division [J].

Brown, KE ;

Baxter, J ;

Graf, D ;

Merkenschlager, M ;

Fisher, AG .

MOLECULAR CELL, 1999, 3 (02) :207-217

[9] Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells [J].

Brown, KE ;

Amoils, S ;

Horn, JM ;

Buckle, VJ ;

Higgs, DR ;

Merkenschlager, M ;

Fisher, AG .

NATURE CELL BIOLOGY, 2001, 3 (06) :602-606

[10] Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin [J].

Brown, KE ;

Guest, SS ;

Smale, ST ;

Hahm, K ;

Merkenschlager, M ;

Fisher, AG .

CELL, 1997, 91 (06) :845-854

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