Creme de la Kremen of Wnt signalling inhibition

被引：21

作者：

Rothbächer, U ^{[1
]}

Lemaire, P ^{[1
]}

机构：

[1] Univ Mediterranee, CNRS, Lab Genet & Physiol Dev, Inst Dev Biol Marseille, F-13288 Marseille, France

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1038/ncb0702-e172

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic development depends on spatially regulated signals that function locally to change the fate or shape of cells. Recent advances have shed light on a sophisticated mechanism of Wnt signal inhibition, whereby an activating coreceptor, LDL-receptor-related protein 6 (LRP6), is segregated away by a secreted inhibitor (Dickkopf) and removed by internalization after interaction with the membrane-anchored protein, Kremen.

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收藏

页码：E172 / E173

页数：2

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