Synthesis of cyclic peptides modelled on the microcystin and nodularin rings.

被引：14

作者：

Taylor, C

Quinn, RJ

Alewood, P

机构：

[1] GRIFFITH UNIV,QUEENSLAND PHARMACEUT RES INST,BRISBANE,QLD 4111,AUSTRALIA

[2] UNIV QUEENSLAND,3D CTR DRUG DESIGN & DEV,BRISBANE,QLD 4072,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00377-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several precursor cyclic peptides modelled on the ring systems of microcystin-LR and nodularin were synthesized. Synthesis was best achieved using solid-phase cyclization with solution-phase methods being successful in only one instance. These precursor cyclic peptides are suitable for elaboration with Adda-like hydrophobic side chains in order to produce structure-activity information. Copyright (C) 1996 Elsevier Science Ltd

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页码：2107 / 2112

页数：6

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