Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

被引：87

作者：

Bruns, Danielle R. ^{[1
]}

Drake, Joshua C. ^{[1
]}

Biela, Laurie M. ^{[1
]}

Peelor, Frederick F., III ^{[1
]}

Miller, Benjamin F. ^{[1
]}

Hamilton, Karyn L. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2015年 / 2015卷

关键词：

NAKED MOLE-RAT; TRANSCRIPTION FACTOR NRF2; INCREASES LIFE-SPAN; AGE-RELATED-CHANGES; CALORIC RESTRICTION; OXIDATIVE STRESS; DIETARY RESTRICTION; LIVING RODENT; ANTIOXIDANT MECHANISMS; REACTIVE OXYGEN;

D O I：

10.1155/2015/732596

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor nuclear factor ( erythroid-derived 2)-like 2 is the "master regulator" of cellular antioxidant defenses. Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity. However, Nrf2 expression and activity in long-lived models have not been well described. Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means.

引用

页数：15

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