New O-superfamily conotoxins from Conus striatus inhabited near Chinese Hainan Island

被引：4

作者：

Lu, BS ^{[1
]}

Yu, F ^{[1
]}

Wang, JH ^{[1
]}

Zhao, SQ ^{[1
]}

Zhao, D ^{[1
]}

Dai, QY ^{[1
]}

Huang, PT ^{[1
]}

Huang, CF ^{[1
]}

机构：

[1] Inst Biotechnol, Beijing 100071, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2000年 / 45卷 / 05期

关键词：

conotoxin; RACE; conopeptide; Conus striatus; O-superfamily conotoxin;

D O I：

10.1007/BF02884945

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Conotoxins are short peptide-toxins with specific targets and large diversity. They are useful in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. In order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3' cDNA ends (RACE) method was utilized to systemically analyze the O-superfamily conotoxin content of Conus striatus inhabited near Chinese Hainan Island. Six new O-superfamily conopeptides were identified, one of which is highly homologous to MVIIA, an N-type calcium channel antagonist.

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收藏

页码：432 / 435

页数：4

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