Three new triterpenoids from Peganum nigellastrum

被引：25

作者：

Ma, ZZ

Hano, Y

Nomura, T ^{[1
]}

Chen, YJ

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan

[2] Shenyang Pharmaceut Univ, Shenyang 110015, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 03期

关键词：

D O I：

10.1021/np990227b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new triterpenoids, 3 alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3 alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3 alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were isolated from the roots of Peganum nigellastrum along with four known lupene-type triterpenoids. The structures of the new triterpenoids were determined by NMR spectroscopic means. The new triterpene, 3 alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester is a DNA topoisomerase II inhibitor (IC50 = 8.9 mu M/mL).

引用

页码：390 / 392

页数：3

共 14 条

[1]

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[2]

BATSUREN D, 1980, KHIM PRIR SOEDIN+, P736

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