Bone marrow-derived CD13+ cells sustain tumor progression A potential non-malignant target for anticancer therapy

被引：4

作者：

Dondossola, Eleonora ^{[1
]}

Corti, Angelo ^{[2
]}

Sidman, Richard L. ^{[3
,4
]}

Arap, Wadih ^{[5
,6
,7
]}

Pasqualini, Renata ^{[5
,6
,7
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, David H Koch Ctr, Houston, TX 77030 USA

[2] Ist Sci San Raffaele, Div Mol Oncol, I-20132 Milan, Italy

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[5] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA

[6] Univ New Mexico, Sch Med, Dept Internal Med, Div Hematol Oncol, Albuquerque, NM 87131 USA

[7] Univ New Mexico, Sch Med, Dept Internal Med, Div Mol Med, Albuquerque, NM 87131 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

angiogenesis; tumor; CD13; mouse models; bone marrow-derived cells; AMINOPEPTIDASE N; ANGIOGENESIS; CANCER;

D O I：

10.4161/onci.27716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Non-malignant cells found within neoplastic lesions express alanyl (membrane) aminopeptidase (ANPEP, best known as CD13), and CD13-null mice exhibit limited tumor growth and angiogenesis. We have recently demonstrated that a subset of bone marrow-derived CD11b(+)CD13(+) myeloid cells accumulate within neoplastic lesions in several murine models of transplantable cancer to promote angiogenesis. If these findings were confirmed in clinical settings, CD11b(+)CD13(+) myeloid cells could become a non-malignant target for the development of novel anticancer regimens.

引用

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