Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARα

被引：5

作者：

Bougarne, Nadia ^{[1
]}

Paumelle, Rejane ^{[2
]}

Haegeman, Guy ^{[1
]}

Staels, Bart ^{[2
]}

De Bosscher, Karolien ^{[1
]}

机构：

[1] Univ Ghent, Dept Physiol, LEGEST, B-9000 Ghent, Belgium

[2] Univ Lille Nord France, Inst Pasteur Lille, INSERM, Lille, France

来源：

CELL CYCLE | 2009年 / 8卷 / 15期

关键词：

glucocorticoid receptor; PPAR; inflammation; NF kappa B; hyperinsulinemia; cross-talk; transcription; KAPPA-B; RECEPTOR-ALPHA; NUCLEAR RECEPTORS; TRANSCRIPTION; METABOLISM; INDUCTION; ROLES;

D O I：

10.4161/cc.8.15.9220

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：2311 / 2312

页数：2

共 15 条

[1] Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation [J].

Blanquart, C ;

Barbier, O ;

Fruchart, JC ;

Staels, B ;

Glineur, C .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 85 (2-5) :267-273

[2] PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB [J].

Bougarne, Nadia ;

Paumelle, Rejane ;

Caron, Sandrine ;

Hennuyer, Nathalie ;

Mansouri, Roxane ;

Gervois, Philippe ;

Staels, Bart ;

Haegeman, Guy ;

De Bosscher, Karolien .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (18) :7397-7402

[3] Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR [J].

Chinetti, G. ;

Fruchart, J. C. ;

Staels, B. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 :1128-1131

[4] Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation [J].

Chinetti, G ;

Fruchart, JC ;

Staels, B .

INFLAMMATION RESEARCH, 2000, 49 (10) :497-505

[5] The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1:: Molecular mechanisms for gene repression [J].

De Bosscher, K ;

Vanden Berghe, W ;

Haegeman, G .

ENDOCRINE REVIEWS, 2003, 24 (04) :488-522

[6] Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1 [J].

Delerive, P ;

De Bosscher, K ;

Besnard, S ;

Vanden Berghe, W ;

Peters, JM ;

Gonzalez, FJ ;

Fruchart, JC ;

Tedgui, A ;

Haegeman, G ;

Staels, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) :32048-32054

[7] DNA binding-independent induction of IκBα gene transcription by PPARα [J].

Delerive, P ;

De Bosscher, K ;

Vanden Berghe, W ;

Fruchart, JC ;

Haegeman, G ;

Staels, B .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (05) :1029-1039

[8] Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators [J].

Delerive, P ;

Gervois, P ;

Fruchart, JC ;

Staels, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36703-36707

[9] Peroxisome proliferator-activated receptors at the crossroads of obesity, diabetes, and cardiovascular disease [J].

Gilde, Andries J. ;

Fruchart, Jean-Charles ;

Staels, Bart .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (09) :A24-A32

[10] Sorting out the roles of PPARα in energy metabolism and vascular horneostasis [J].

Lefebvre, P ;

Chinetti, G ;

Fruchart, JC ;

Staels, B .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :571-580

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