Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand

被引：17

作者：

Esche, C

Subbotin, VM

Hunter, O

Peron, JM

Maliszewski, C

Lotze, MT

Shurin, MR

机构：

[1] Univ Pittsburgh, Inst Canc, Div Surg Oncol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA

[4] Immunex Corp, Washington, DC USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1999年 / 113卷 / 06期

关键词：

antigen-presenting cell; cell trafficking; cytokine; Langerhans cell;

D O I：

10.1046/j.1523-1747.1999.00779.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

An abrogation of the decline in epidermal Langerhans cell numbers above melanoma might significantly improve the efficacy of immunotherapy for melanoma treatment. Systemic Flt3 ligand (FL) administration in mice induced a significant increase in mature dendritic cells (DC) within the skin, preferentially in the dermis, whereas IL-12 promoted a significant increase of immature DC preferentially in the epidermis. Both effects were abrogated in IL-12 knockout mice. Thus, IL-12 could promote FL-induced accumulation of skin DC. The involvement of FL and IL-12 in the regulation of DC accumulation within the skin may contribute, at least in part, to the stimulation of antimelanoma immunity by FG and IL-12-based immunotherapies. Moreover, FL and IL-12 could be used for selective in vivo generation of DC in either epidermis or dermis for experimental and clinical purposes.

引用

页码：1028 / 1032

页数：5

共 32 条

[11] LANGERHANS CELLS IN VARIOUS BENIGN AND MALIGNANT PIGMENT-CELL LESIONS OF THE SKIN [J].