DASMI: exchanging, annotating and assessing molecular interaction data

被引：11

作者：

Blankenburg, Hagen ^{[1
]}

Finn, Robert D. ^{[2
]}

Prlic, Andreas ^{[2
]}

Jenkinson, Andrew M. ^{[3
]}

Ramirez, Fidel ^{[1
]}

Emig, Dorothea ^{[1
]}

Schelhorn, Sven-Eric ^{[1
]}

Buech, Joachim ^{[1
]}

Lengauer, Thomas ^{[1
]}

Albrecht, Mario ^{[1
]}

机构：

[1] Max Planck Inst Informat, D-66123 Saarbrucken, Germany

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

BIOINFORMATICS | 2009年 / 25卷 / 10期

关键词：

PROTEIN-PROTEIN INTERACTIONS; DOMAIN-DOMAIN INTERACTIONS; OPEN-SOURCE SOFTWARE; INTERACTION NETWORK; FUNCTIONAL SIMILARITY; PREDICTION; BIOINFORMATICS; VISUALIZATION; INFORMATION; INTEGRATION;

D O I：

10.1093/bioinformatics/btp142

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Ever increasing amounts of biological interaction data are being accumulated worldwide, but they are currently not readily accessible to the biologist at a single site. New techniques are required for retrieving, sharing and presenting data spread over the Internet. Results: We introduce the DASMI system for the dynamic exchange, annotation and assessment of molecular interaction data. DASMI is based on the widely used Distributed Annotation System (DAS) and consists of a data exchange specification, web servers for providing the interaction data and clients for data integration and visualization. The decentralized architecture of DASMI affords the online retrieval of the most recent data from distributed sources and databases. DASMI can also be extended easily by adding new data sources and clients. We describe all DASMI components and demonstrate their use for protein and domain interactions.

引用

页码：1321 / 1328

页数：8

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