Prenatal stress induces a phase advance of circadian corticosterone rhythm in adult rats which is prevented by postnatal stress

被引：65

作者：

Koehl, M ^{[1
]}

Barbazanges, A ^{[1
]}

LeMoal, M ^{[1
]}

Maccari, S ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,INSERM,U259,F-33077 BORDEAUX,FRANCE

来源：

BRAIN RESEARCH | 1997年 / 759卷 / 02期

关键词：

development; critical period; prenatal stress; postnatal stress; corticosterone; rhythm;

D O I：

10.1016/S0006-8993(97)00394-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prenatal and postnatal stressors can have different long-term neuroendocrine effects including modifications of stress-induced corticosterone secretion. However, very little is known about the possible long-term effects of prenatal or postnatal stress on the rhythmicity of basal corticosterone secretion in adult offspring. Corticosterone levels were thus determined at six different time points over 24 h in adult rats whose mothers had undergone restraint stress manipulations. The results demonstrate that prenatal stress induces a phase advance in the evening increase of corticosterone levels, and that this change is prevented by postnatal stress. It thus appears that the circadian system governing the HPA axis is modifiable by a prenatal stress, and remains susceptible to compensatory changes during the postnatal period. (C) 1997 Elsevier Science B.V.

引用

页码：317 / 320

页数：4