Safety and tolerability of gamma-hydroxybutyric acid in the treatment of alcohol-dependent patients

被引：35

作者：

Beghè, F

Carpanini, MT

机构：

[1] Lab Farmaceut CT, Clin & Pharmacol Res Unit Piertomaso Tessitore, I-18038 Sanremo, Italy

[2] Lab Farmaceut CT, Pharmacosurveillance Dept, I-18038 Sanremo, Italy

来源：

ALCOHOL | 2000年 / 20卷 / 03期

关键词：

abuse potential; alcohol; alcoholism; gamma-hydroxybutyric acid;

D O I：

10.1016/S0741-8329(99)00085-3

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Gamma-hydroxybutyric acid (GI-IB) has been in clinical use in Italy since 1991 for treatment of alcohol dependence. Results of phase III and phase IV studies have shown that the drug is effective and well tolerated in the treatment of alcohol withdrawal syndrome and in reducing alcohol consumption and alcohol craving. Pharmacosurveillance indicates that abuse of gamma-hydroxybutyric acid is a limited phenomenon in clinical settings when the drug is dispensed under strict medical surveillance and entrusted to a referring familiar member of the patient. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：223 / 225

页数：3

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