Mesenchymal stromal cells: tissue repair and immune modulation

被引：236

作者：

Le Blanc, K. ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Ctr Allogene Stem Cell Transplantat, S-10401 Stockholm, Sweden

来源：

CYTOTHERAPY | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1080/14653240601045399

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

BM-derived mesenchymal stromal cells (MSC) differentiate along the mesenchymal lineage to bone, fat and cartilage. In vitro, MSC induce little, if any, proliferation of allogeneic lymphocytes. MSC inhibit the proliferation of activated T cells and the formation of cytotoxic T cells. In vivo, they appear to have anti-inflammatory effects. Preliminary studies suggest that MSC preferentially home to damaged tissue and therefore have therapeutic potential. Possible clinical indications include therapy-resistant severe acute GvHD, treatment of rejection of organ allografts and autoimmune disorders.

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页码：559 / 561

页数：3

相关论文

共 18 条

[1]

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[2]

CASTROMALASPINA H, 1980, BLOOD, V56, P289

[3]

HETEROTOPIC TRANSPLANTS OF BONE MARROW - ANALYSIS OF PRECURSOR CELLS FOR OSTEOGENIC AND HEMATOPOIETIC TISSUES [J].

FRIEDENSTEIN, AJ ;

PETRAKOVA, KV ;

KUROLESOVA, AI ;

FROLOVA, GP .

TRANSPLANTATION, 1968, 6 (02) :230-+

[4]

Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium [J].

Grinnemo, KH ;

Månsson, A ;

Dellgren, G ;

Klingberg, D ;

Wardell, E ;

Drvota, V ;

Tammik, C ;

Holgersson, J ;

Ringdén, O ;

Sylvén, C ;

Le Blanc, K .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2004, 127 (05) :1293-1300

[5]

Clarification of the nomenclature for MSC: The international society for cellular therapy position statement [J].

Horwitz, EM ;

Le Blanc, K ;

Dominici, M ;

Mueller, I ;

Slaper-Cortenbach, I ;

Marini, FC ;

Deans, RJ ;

Krause, DS ;

Keating, A .

CYTOTHERAPY, 2005, 7 (05) :393-395

[6]

Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells [J].

Jones, EA ;

Kinsey, SE ;

English, A ;

Jones, RA ;

Straszynski, L ;

Meredith, DM ;

Markham, AF ;

Jack, A ;

Emery, P ;

McGonagle, D .

ARTHRITIS AND RHEUMATISM, 2002, 46 (12) :3349-3360

[7]

T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression [J].

Klyushnenkova, E ;

Mosca, JD ;

Zernetkina, V ;

Majumdar, MK ;

Beggs, KJ ;

Simonetti, DW ;

Deans, RJ ;

McIntosh, KR .

JOURNAL OF BIOMEDICAL SCIENCE, 2005, 12 (01) :47-57

[8]

Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta [J].

Le Blanc, K ;

Götherström, C ;

Ringdén, O ;

Hassan, M ;

McMahon, R ;

Horwitz, E ;

Anneren, G ;

Axelsson, O ;

Nunn, J ;

Ewald, U ;

Nordén-Lindeberg, S ;

Jansson, M ;

Dalton, A ;

Åström, E ;

Westgren, M .

TRANSPLANTATION, 2005, 79 (11) :1607-1614

[9]

HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells [J].

Le Blanc, K ;

Tammik, C ;

Rosendahl, K ;

Zetterberg, E ;

Ringdén, O .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (10) :890-896

[10]

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells [J].

Le Blanc, K ;

Rasmusson, I ;

Sundberg, B ;

Götherström, C ;

Hassan, M ;

Uzunel, M ;

Ringdén, O .

LANCET, 2004, 363 (9419) :1439-1441