Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis

被引：108

作者：

Sawa, Hidehiro

Ueda, Takashi

Takeyama, Yoshifumi

Yasuda, Takeo

Shinzeki, Makoto

Nakajima, Takahiro

Kuroda, Yoshikazu

机构：

[1] Kobe Univ, Grad Sch Med Sci, Dept Surg Gastroenterol, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kinki Univ, Sch Med, Dept Surg, Osaka 5898511, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 47期

关键词：

severe acute pancreatitis; high mobility group box-1; neutralizing antibody; inflammatory response; organ dysfunction; bacterial translocation;

D O I：

10.3748/wjg.v12.i47.7666

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental severe acute pancreatitis (SAP). METHODS: SAP was induced by creating closed duodenal loop in C3H/HeN mice. SAP was induced immediately after intraperitoneal injection of anti-HMGB1 neutralizing antibody (200 mu g). Severity of pancreatitis, organ injury (liver, kidney and lung), and bacterial translocation to pancreas was examined 12 h after induction of SAP. RESULTS: Anti-HMGB1 neutralizing antibody significantly improved the elevation of the serum amylase level and the histological alterations of pancreas and lung in SAR Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and creatinine in SAR However, anti-HMGB1 antibody worsened the bacterial translocation to pancreas. CONCLUSION: Blockade of HMGB1 attenuated the development of SAP and associated organ dysfunction, suggesting that HMGB1 may act as a key mediator for inflammatory response and organ injury in SAP. (c) 2006 The WJG Press. All rights reserved.

引用

页码：7666 / 7670

页数：5

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