Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function

被引：4

作者：

Bartlett, S

Nelson, A ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b400078a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of macrocycle size and substitution on the configurational stability of some bisindolylmaleimide cyclophanes was determined.

引用

页码：1112 / 1113

页数：2

共 13 条

[1] The stereochemistry of diphenyls and analogous compounds [J].

Adams, R ;

Yuan, HC .

CHEMICAL REVIEWS, 1933, 12 (02) :261-338

[2] INHIBITORS OF PROTEIN-KINASE-C .3. POTENT AND HIGHLY SELECTIVE BISINDOLYLMALEIMIDES BY CONFORMATIONAL RESTRICTION [J].

BIT, RA ;

DAVIS, PD ;

ELLIOTT, LH ;

HARRIS, W ;

HILL, CH ;

KEECH, E ;

KUMAR, H ;

LAWTON, G ;

MAW, A ;

NIXON, JS ;

VESEY, DR ;

WADSWORTH, J ;

WILKINSON, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) :21-29

[3]

BUDZELAAR CP, GNMR VER 5 0

[4] STERIC EFFECTS .8. RACEMIZATION OF CHIRAL BIPHENYLS [J].

CHARTON, M .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (14) :2528-2529

[5] INHIBITORS OF PROTEIN-KINASE-C .1. 2,3-BISARYLMALEIMIDES [J].

DAVIS, PD ;

HILL, CH ;

LAWTON, G ;

NIXON, JS ;

WILKINSON, SE ;

HURST, SA ;

KEECH, E ;

TURNER, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :177-184

[6]

HEATH WF, 1995, Patent No. 657458

[7] (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase C beta [J].

Jirousek, MR ;

Gillig, JR ;

Gonzalez, CM ;

Heath, WF ;

McDonald, JH ;

Neel, DA ;

Rito, CJ ;

Singh, U ;

Stramm, LE ;

MelikianBadalian, A ;

Baevsky, M ;

Ballas, LM ;

Hall, SE ;

Winneroski, LL ;

Faul, MM .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (14) :2664-2671

[8] STAUROSPORINE, K-252 AND UCN-01 - POTENT BUT NONSPECIFIC INHIBITORS OF PROTEIN-KINASES [J].

RUEGG, UT ;

BURGESS, GM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (06) :218-220

[9] A CONFORMATIONAL STUDY OF [3.3]METACYCLOPHANES THROUGH VARIABLE-TEMPERATURE H-1-NMR AND OPTICAL-ROTATION [J].

SAKO, K ;

SHINMYOZU, T ;

TAKEMURA, H ;

SUENAGA, M ;

INAZU, T .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (24) :6536-6541

[10]

TOULLEC D, 1991, J BIOL CHEM, V266, P15771

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