Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats

被引：58

作者：

Zeng, Bai-Yun ^{[1
]}

Bukhatwa, Salma ^{[1
]}

Hikima, Atsuko ^{[1
]}

Rose, Sarah ^{[1
]}

Jenner, Peter ^{[1
]}

机构：

[1] Kings Coll London, Sch Hlth & Biomed Sci, NDRC, London SE1 1UL, England

来源：

ANNALS OF NEUROLOGY | 2006年 / 60卷 / 02期

关键词：

D O I：

10.1002/ana.20932

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Systemic administration of proteasomal inhibitors to rats has been proposed as producing progressive nigral dopaminergic cell loss and impairment of motor function, although this has proved difficult to reproduce. We report reproducible loss of tyrosine hydroxylase-positive cells in substantia nigra and decrease in locomotor activity by proteasomal inhibitor injection in rats up to 10 months after treatment. Dopaminergic cell death was accompanied by the appearance of ubiquitin and (x-synuclein-positive inclusions in the substantia nigra in these rats. Neuronal loss was also observed in the locus ceruleus, raphe nuclei, and dorsal motor nucleus of the vagus, verifying that proteasomal inhibition produces a relevant model of Parkinson's disease.

引用

页码：248 / 252

页数：5

共 18 条

[1] The proteasomal inhibition model of Parkinson's disease: "Boon or bust"? [J].

Beal, Flint ;

Lang, Anthony .

ANNALS OF NEUROLOGY, 2006, 60 (02) :158-161

[2] Proteasome inhibition and Parkinson's disease modeling [J].

Bove, Jordi ;

Zhou, Chun ;

Jackson-Lewis, Vernice ;

Taylor, Julie ;

Chu, Yaping ;

Rideout, Hardy J. ;

Wu, Du-Chu ;

Kordower, Jeffrey H. ;

Petrucelli, Leonard ;

Przedborski, Serge .

ANNALS OF NEUROLOGY, 2006, 60 (02) :260-264

[3] RELIABILITY OF HOLE-BOARD APPARATUS [J].

FILE, SE ;

WARDILL, AG .

PSYCHOPHARMACOLOGIA, 1975, 44 (01) :47-51

[4] Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins [J].

Hyun, DH ;

Lee, M ;

Halliwell, B ;

Jenner, P .

JOURNAL OF NEUROCHEMISTRY, 2003, 86 (02) :363-373

[5] Oxidative stress in Parkinson's disease [J].

Jenner, P .

ANNALS OF NEUROLOGY, 2003, 53 :S26-S36

[6] Understanding cell death in Parkinson's disease [J].

Jenner, P ;

Olanow, CW .

ANNALS OF NEUROLOGY, 1998, 44 (03) :S72-S84

[7] Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys [J].

Kordower, Jeffrey H. ;

Kanaan, Nicholas M. ;

Chu, Yaping ;

Babu, Rangasamy Suresh ;

Stansell, James, III ;

Terpstra, Brian T. ;

Sortwell, Caryl E. ;

Steece-Collier, Kathy ;

Collier, Timothy J. .

ANNALS OF NEUROLOGY, 2006, 60 (02) :264-268

[8] Lack of nigrostriatal pathology in a rat model of proteasome inhibition [J].

Manning-Bog, Amy B. ;

Reaney, Stephen H. ;

Chou, Vivian P. ;

Johnston, Louisa C. ;

McCormack, Alison L. ;

Johnston, Jennifer ;

Langston, J. William ;

Di Monte, Donato A. .

ANNALS OF NEUROLOGY, 2006, 60 (02) :256-260

[9] Proteasome inhibitor-induced model of Parkinson's disease [J].

McNaught, Kevin St. P. ;

Olanow, C. Warren .

ANNALS OF NEUROLOGY, 2006, 60 (02) :243-247

[10] Proteasome inhibition causes nigral degeneration with inclusion bodies in rats [J].

McNaught, KS ;

Björklund, LM ;

Belizaire, R ;

Isacson, O ;

Jenner, P ;

Olanow, CW .

NEUROREPORT, 2002, 13 (11) :1437-1441

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