Ubiquitin-proteasome system - From lysosome to proteasome: the power of yeast in the dissection of proteinase function in cellular regulation and waste disposal

被引：24

作者：

Wolf, DH ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Biochem, D-70569 Stuttgart, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 13期

关键词：

yeast; ubiquitin; proteasome; vacuole/lysosome; catabolite degradation; ERAD; ER-quality control;

D O I：

10.1007/s00018-004-4134-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The yeast Saccharomyces cerevisiae has turned out to be an invaluable tool in the molecular biological sciences for elucidating the housekeeping functions of eukaryotic cells. Due to its easy amenability to biochemical, genetic, molecular biological and cell biological experimentation, including genomics and proteomics, yeast has become one of the most frequently used eukaryotic model organisms. One of the fields where studies in yeast have a truly pacemaking character is cellular control by proteolysis. The function of vacuolar (lysosomal) proteolysis was elucidated. The in vivo role of ubiquitin and its relation to the proteasome was uncovered. This research led to an avalanche of studies in many different eukaryotic systems, including mammals, and provided us with surprising new insights in cellular control in health and disease.

引用

页码：1601 / 1614

页数：14

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