New fascaplysin-based CDK4-specific inhibitors:: design, synthesis and biological activity

被引：32

作者：

Aubry, C

Jenkins, PR ^{[1
]}

Mahale, S

Chaudhuri, B

Maréchal, JD

Sutcliffe, MJ

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] De Montfort Univ, Sch Pharm, Leicester LE1 9BH, Leics, England

[3] Univ Leicester, Dept Biochem & Chem, Leicester LE1 7RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 15期

关键词：

D O I：

10.1039/b406076h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first biologically active non-planar analogues of the toxic anti-cancer agent, fascaplysin, have been produced; we present the design, synthesis and biological activity of three tryptamine derivatives.

引用

页码：1696 / 1697

页数：2