Agent-based modeling of host-pathogen systems: The successes and challenges

被引：143

作者：

Bauer, Amy L. ^{[2
]}

Beauchemin, Catherine A. A. ^{[1
,3
]}

Perelson, Alan S. ^{[1
]}

机构：

[1] Los Alamos Natl Lab, Ctr Nonlinear Studies, Los Alamos, NM 87545 USA

[2] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA

[3] Ryerson Univ, Dept Phys, Toronto, ON, Canada

来源：

INFORMATION SCIENCES | 2009年 / 179卷 / 10期

关键词：

Agent-based model; Host-pathogen dyamics; Artificial immune system; Multiscale; Tumor growth; Tuberculosis; Acute inflammation; Sensitivity analysis; CELLULAR-AUTOMATON MODEL; NON-SELF DISCRIMINATION; SHAPE-SPACE MODEL; H TH GENESIS; IN-VITRO; SPATIAL HETEROGENEITY; COMPUTERIZED MODEL; IMMUNE-RESPONSE; DENDRITIC CELLS; VIRUS-INFECTION;

D O I：

10.1016/j.ins.2008.11.012

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance out understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological processes. We then point out some limitations and challenges of agent-based models and encourage efforts towards reproducibility and model validation. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1379 / 1389

页数：11

共 108 条

[1] A multiple scale model for tumor growth [J].

Alarcón, T ;

Byrne, HM ;

Maini, PK .

MULTISCALE MODELING & SIMULATION, 2005, 3 (02) :440-475

[2] Concepts for developing a collaborative in silico model of the acute inflammatory response using agent-based modeling [J].

An, G .

JOURNAL OF CRITICAL CARE, 2006, 21 (01) :105-110

[3] In silico experiments of existing and hypothetical cytokine-diyected clinical trials using agent-based modeling [J].

An, G .

CRITICAL CARE MEDICINE, 2004, 32 (10) :2050-2060

[4] Agent-based computer simulation and SIRS: Building a bridge between basic science and clinical trials [J].

An, G .

SHOCK, 2001, 16 (04) :266-273

[5]

[Anonymous], THESIS U NEW MEXICO

[6] Kinetics of influenza A virus infection in humans [J].

Baccam, Prasith ;

Beauchemin, Catherine ;

Macken, Catherine A. ;

Hayden, Frederick G. ;

Perelson, Alan S. .

JOURNAL OF VIROLOGY, 2006, 80 (15) :7590-7599

[7] Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes [J].

Bajenoff, Marc ;

Egen, Jackson G. ;

Koo, Lily Y. ;

Laugier, Jean Pierre ;

Brau, Frederic ;

Glaichenhaus, Nicolas ;

Germain, Ronald N. .

IMMUNITY, 2006, 25 (06) :989-1001

[8] An enhanced agent based model of the immune system response [J].

Baldazzi, V. ;

Castiglione, F. ;

Bernaschi, M. .

CELLULAR IMMUNOLOGY, 2006, 244 (02) :77-79

[9]

BARDI JS, 2006, NEW NIAID PROGRAM AI

[10] A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis [J].

Bauer, Amy L. ;

Jackson, Trachette L. ;

Jiang, Yi .

BIOPHYSICAL JOURNAL, 2007, 92 (09) :3105-3121

← 1 2 3 4 5 6 7 8 9 10 →